J. Eames et al., Stereochemically controlled synthesis of 1,8-dioxaspiro[4.5]decanes and 1-oxa-8-thiaspiro[4.5]decanes by phenylsulfanyl migration, J CHEM S P1, (12), 2000, pp. 1903-1914
Single enantiomers and diastereoisomers of 2- and 3-alkyl-3-phenylsulfanyl-
1,8-dioxa- and 1-oxa-8-thiaspiro[4.5]decanes can be prepared in good yield
by acid-catalysed phenylsulfanyl (PhS-) migration. Either the syn- or anti-
stereochemistry can be controlled by aldol reactions or by reduction of hyd
roxy-ketones.