In this longitudinal, multiple case study, I describe and compare the early
development, instructional history, repeated administrations of a test bat
tery, and response to instructional intervention for seven boys (in third t
o at time of intervention), who were brain imaged prior to intervention and
found to differ from controls in brain chemical activation during a phonol
ogical task. The instructional intervention was phonologically driven readi
ng instruction in a science/reading workshop. At follow-up, phonological sk
ills (phonological manipulation, phonological memory, and phonological deco
ding) had improved compared to initial assessment, but the boys were better
at silent reading comprehension than oral reading, and had rate impairment
s and considerable difficulties with writing skills (handwriting automatici
ty, spelling, and speed of composing). Based on recent research on genetic
phenotype (language markers) and on early intervention, a case is made that
dyslexia should be diagnosed early in schooling, on the basis or markers f
or deficient language processes and response to early intervention, so that
appropriate instruction can be instituted early and continued throughout s
chooling as long as necessary. Dyslexia is a developmental disorder that ma
nifests in different ways at different developmental stages, initially as d
ifficulty in learning letters and letter-sound correspondence, next in lear
ning to read words accurately, and finally in impaired reading rate and wri
tten expression skills (handwriting automaticity, spelling, and composition
al fluency).