Parvovirus-mediated antineoplastic activity exploits genome instability

Authors
Shadan, FF Villarreal, LP
Citation
Ff. Shadan et Lp. Villarreal, Parvovirus-mediated antineoplastic activity exploits genome instability, MED HYPOTH, 55(1), 2000, pp. 1-4
Citations number
61
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MEDICAL HYPOTHESES
ISSN journal
03069877 → ACNP
Volume
55
Issue
1
Year of publication
2000
Pages
1 - 4
Database
ISI
SICI code
0306-9877(200007)55:1<1:PAAEGI>2.0.ZU;2-C
Abstract
The generation and accumulation of genetic mutations have been associated w ith carcinogenesis. Epidemiological and experimental evidence implicate par voviruses in growth inhibition (oncosuppression) and selective destruction (oncolysis) of tumor cells. It is proposed here that parvoviruses can prefe rentially target genetically unstable tumor cells, which are deficient in D NA repair mechanisms. This selective strategy may serve as a virus-based th erapeutic approach against cancer. (C) 2000 Harcourt Publishers Ltd.