Neonatal management at limits of hypothesis based on viability: hypothesisbased on review of literature and clinical observations

Advances in the surfactant era have resulted in a dramatic rise in the surv ival of 23-26 week old neonates. For the group as a whole, survival is 50% with a 50% morbidity in survivors. Current literature includes a few 'small baby protocols' suggesting guidelines for management based on institutiona l experiences. Adopting these with or without any modifications may not be appropriate for other institutions due to the diversity of the patient popu lation involved and the available resources. A review of literature on ELBW neonates reveals an interesting fact that almost all the management strate gies and optimal goals in the most critical first few weeks of life involve two numbers - 'fifty' and 'eight'! The relevance of these two numbers (or their multiples) in simplifying the management of ELBW neonates is highligh ted. (C) 2000 Harcourt Publishers Ltd.