Synthesis and pharmacological characterization of new analogs of broxaterol

Authors
De Amici, M Conti, P Dallanoce, C Kassi, L Castellano, S Stefancich, G De Micheli, C
Citation
M. De Amici et al., Synthesis and pharmacological characterization of new analogs of broxaterol, MED CHEM RE, 10(2), 2000, pp. 69-80
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
69 - 80
Database
ISI
SICI code
1054-2523(2000)10:2<69:SAPCON>2.0.ZU;2-K
Abstract
A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to beta(1) and beta(2) adrenergi c receptors. At variance with broxaterol, none of the tested compounds disp layed agonistic activity. The 3-isopropenyl derivative 5f is the most poten t antagonist both in the trachea and atria preparations.