Transient increase of brain derived neurotrophic factor mRNA expression insubstantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway
E. Aliaga et al., Transient increase of brain derived neurotrophic factor mRNA expression insubstantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway, MOL BRAIN R, 79(1-2), 2000, pp. 150-155
By using non-isostopic in situ hybridization we have demonstrated a transie
nt increase of BDNF mRNA in the lateral subregion of the substantia nigra p
ars reticulata 1 week after intrastriatal application of 6-OH-DA. These cha
nges correlate with a partial reduction of dopamine (DA) content in the str
iatum but with a normal tyrosine hydroxylase immunoreactivity in substantia
nigra pars compacta. Our data suggest that non-DA, BDNF expressing cells i
n substantia nigra pars reticulata may play a role in neuronal protection a
fter partial lesions of the DA nigrostriatal pathway. (C) 2000 Elsevier Sci
ence B.V. All rights reserved.