Treatment by midodrine (Gutron (R)) for permanent arterial hypotension in a chronic dialyzed patient

Chronic hypotension, although unfrequent in uremic patients on hemodialysis , accentuates the deterioration of patients physical state and thus, their general weil-being. These patients often experience acute intradialytic sym ptoms and respond very poorly to conventional therapies, Well tolerated, mi dodrine is a suitable and effective choice as it raises blood pressure sign ificantly through its effect on peripheral alpha-adrenergic receptors. The authors report observing the use of midodrine by a dialysis patient dur ing the longest time period published to date, documented by a pharmacokine tic study, and that confirms the excellent results and proves long term tol erance for that drug.