SYNTHESIS OF N-SUBSTITUTED 2,4-DIAMINOTHIAZOLES AND THEIR SALTS

A series of N(2),N(4)-substituted 2,4-diaminothiazoles (22) and their corresponding mineral acid salts (22.HX) and (22.2HX) have been prepar ed by the reaction of POCl3 with N-substituted S-(dialkylaminocarbonyl methylene)isothiouronium salts (20) available from corresponding subst ituted thioureas (18) and N,N-disubstituted chloroacetamides (19) or b y the reaction of primary or secondary amines (25) in excess with N(2) -unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochl orides (24) available by the reaction of corresponding N-substituted t hioureas (18) with chloroacetonitrile (23).