A NOVEL METHOD OF PREPARATION OF 3-ACYLIMIDAZO[1,2-A]PYRIDINES

Authors
MOUTOU JL SCHMITT M COLLOT V BOURGUIGNON JJ
Citation
Jl. Moutou et al., A NOVEL METHOD OF PREPARATION OF 3-ACYLIMIDAZO[1,2-A]PYRIDINES, Heterocycles, 45(5), 1997, pp. 897-910
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
45
Issue
5
Year of publication
1997
Pages
897 - 910
Database
ISI
SICI code
0385-5414(1997)45:5<897:ANMOPO>2.0.ZU;2-M
Abstract
A series of 2-substituted 3-acylimidazo[1,2-a]pyridines were synthesiz ed in good to moderate yields from secondary amidino ketones and bromi ne in acetic acid. Cyclocondensation of the alpha-bromo-beta-amidino k etones (6) led to the corresponding trans-dihydroimidazoles (13), whic h may yield spontaneously the stable 3-acylimidazo[1,2-a]pyridines (2) after dehydrogenation.