MODEL STUDY FOR THE CONSTRUCTION OF C-RING OF PIMARA TYPE DITERPENES

Authors
FUKUMOTO T OGUCHI M KASHIBUCHI Y KATO T
Citation
T. Fukumoto et al., MODEL STUDY FOR THE CONSTRUCTION OF C-RING OF PIMARA TYPE DITERPENES, Heterocycles, 45(5), 1997, pp. 963-967
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
45
Issue
5
Year of publication
1997
Pages
963 - 967
Database
ISI
SICI code
0385-5414(1997)45:5<963:MSFTCO>2.0.ZU;2-C
Abstract
As the model experiment to explore the construction route of our synth etic intermediat (8), the epoxy alcohol (5) was prepared by Sharpless epoxidation including asymmetric introduction of the epoxide ring. The cyclization of 5 to the diol (6) proceeded in 40% yield by the action of Ti((OPr)-Pr-i)(4) at room temperature. The diol (6) having more th an 90% enantiomeric excess was obtained from the asymmetric epoxide (5 ).