Identification and characterization of the mode of action of MON 65500: A novel inhibitor of ATP export from mitochondria of the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici

MON 65500 represents a novel class of fungicide, the hindered silyl amides, that selectively inhibit the causative agent of "take-all" disease in whea t, Gaeumannomyces graminis var. tritici. This paper indicates that the prim ary mode of action of MON 65500 is the inhibition of transport of the adeni ne nucleotide, ATP, from the mitochondrial matrix. By preventing the export of ATP to the cytosol, all extramitochondrial energy-dependant processes a re disrupted, leading to cell death. (C) 2000 Academic Press.