Intensity modulated arc therapy (IMAT) with centrally blocked rotational fields

A new technique For intensity-modulated beam (IMB) delivery that combines t he features of intensity modulated are therapy (IMAT) with the use of 'clas sical blocks' is proposed. The role of the blocks is to realize the high-gr adient modulation of the intensity profile corresponding to the region to b e protected within the body contour, while the MLC leaves or the secondary collimator defines the rest of the field and delivers intensity-modulated m ultiple rotational segments. The centrally blocked radiation fields are app lied sequentially in several rotations. Each rotation of the pantry is resp onsible for delivering one segment of the optimal intensity profile. The ne w IMAT technique is applied for a treatment geometry represented by an annu lar target volume centrally located within a circular body contour. The ann ulus encompasses a circular critical structure, which is to be protected. T he beam opening and corresponding weight of each segment are determined in two ways. The first method applies a linear optimization algorithm to preca lculated centrally blocked radial dose profiles. These radial profiles are calculated for a set of beam openings, ranging from the largest field that covers the whole planning target volume (PTV) to the smallest, which is I c m larger than the width of the central block. The optimization is subjected to dose homogeneity constraints imposed on a linear combination of these p rofiles and finally delivers the dimensions and weights of the rotational b eams to be used in combination. The second method decomposes into several s ubfields the fluence profile of a rotational beam known to deliver a consta nt dose level to PTV. This fluence profile is determined by using the analy tical method proposed by Brahme for the case of the annular PTV and the con centric organ at risk (OAR). The proper segmentation of this intensity prof ile provides the field sizes and corresponding weights of the subfields to be used in combination. Both methods show that for this particular treatment geometry, three to sev en segments are sufficient to cover the PTV with the 95% dose level and to keep the dose level to the central critical structure under 30% of the maxi mum dose. These results were verified by experimentally delivering the calc ulated segments to radiotherapy verification films sandwiched between two c ylindrical pieces of a pressed-wood phantom. The total beam time for a thre e-field irradiation was 77 s. The predicted and experimental dose profiles along the radius of the phantom agreed to within 5%. Generalization of this technique to real-patient treatment geometry and advantages over other con formal radiotherapy techniques are also discussed.