Evaluation of antidiarrhoeal profile of Jussiaea suffruticosa Linn. extract in rats

Authors
Murugesan, T Ghosh, L Mukherjee, K Das, J Pal, M Saha, BP
Citation
T. Murugesan et al., Evaluation of antidiarrhoeal profile of Jussiaea suffruticosa Linn. extract in rats, PHYTOTHER R, 14(5), 2000, pp. 381-383
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
14
Issue
5
Year of publication
2000
Pages
381 - 383
Database
ISI
SICI code
0951-418X(200008)14:5<381:EOAPOJ>2.0.ZU;2-C
Abstract
The antidiarrhoeal potential of a methanol extract of the aerial parts of J ussiaea suffruticosa Linn, (MEJS) was studied with several experimental mod els of diarrhoea in rats, MEJS treated rats showed significant inhibitory a ctivity against castor oil induced diarrhoea and PGE(2) induced enteropooli ng, It also showed a significant reduction in gastrointestinal motility fol lowing a charcoal meal in rats, The extract exhibited significant antidiarr hoeal potential at doses of 100,200 and 300 mg/kg in all the animal models and thus established the efficacy of MEJS as a potent antidiarrhoeal agent. Copyright (C) 2000 John Wiley & Sons, Ltd.