Several approaches to mammographic interpretation and breast imaging manage
ment have been developed that substantially reduce the frequency of false-p
ositive cases, without meaningfully reducing the detection of nonpalpable f
avorable-prognosis cancers. These approaches can safely and effectively red
uce the recall rate for screening mammography and reduce the rate of benign
tissue diagnosis after full breast imaging work-up. By applying these appr
oaches successfully on a nationwide scale, radiologists can convincingly de
monstrate that the benefits of mammography far outweigh the risks of false-
positive interpretations.