The effect of nitecapone on early graft function in experimental single lung transplantation

Citation
T. Vainikka et al., The effect of nitecapone on early graft function in experimental single lung transplantation, SC CARDIOVA, 34(4), 2000, pp. 415-420
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
SCANDINAVIAN CARDIOVASCULAR JOURNAL
ISSN journal
14017431 → ACNP
Volume
34
Issue
4
Year of publication
2000
Pages
415 - 420
Database
ISI
SICI code
1401-7431(200008)34:4<415:TEONOE>2.0.ZU;2-P
Abstract
Nitecapone is an antioxidant molecule which has been shown to protect the h eart against ischemia-reperfusion injury. We investigated whether a similar effect could be detected on lung graft preservation in a porcine model of single lung transplantation. Donors received either nitecapone or placebo i n a modified Euro-Collins pulmonary flush solution. After cold storage for 19 h the left lung was transplanted. Patients in the nitecapone group recei ved a nitecapone infusion during the graft reperfusion. A right-side heart bypass was used to measure flow distribution and pulmonary vascular resista nce (PVR) in the recipient's transplanted and native lungs, respectively. P ulmonary vein blood samples were analyzed for blood gases, free radical tra pping capacity and diene conjugates. PVR was high in the transplanted lung, which received only 20% of the blood flow. Oxygen tension in the transplan ted lung was low (2.3-26.7 kPa). Nitecapone treatment increased the plasma free radical trapping capacity threefold. In spite of this increase in anti oxidative capacity nitecapone could not protect the lung against ischemia-r eperfusion injury when pulmonary hemodynamics, gas exchange or plasma diene conjugates were used as measures of lung graft function.