An ISFET-based anion sensor for the potentiometric detection of organic acids in liquid chromatography

An ion-selective field effect transistor (ISFET) was applied as a potentiom etric detector in liquid chromatography (LC) for the determination of organ ic acids. The ISFET was prepared by coating the gate insulator of the encap sulated transistor with a poly(vinyl chloride) (PVC) matrix membrane contai ning methyltridodecylammoniumchloride, which enables the detection of organ ic anions. The ISFET was tested for its applicability as detector for carbo xylic acids in ion-exchange and reversed-phase chromatography. Its analytic al characteristics were compared to those of a coated-wire electrode (CWE) and of a conventional type of ion-selective electrode (ISE). (C) 2000 Elsev ier Science S.A. All rights reserved.