Efficacy and safety of efavirenz in combination with NRTI in HIV positive patients

Citation
E. Raise et al., Efficacy and safety of efavirenz in combination with NRTI in HIV positive patients, SEVENTH EUROPEAN CONFERENCE ON CLINICAL ASPECTS AND TREATMENT OF HIV-INFECTION, 1999, pp. 107-110
Citations number
9
Categorie Soggetti
Current Book Contents
Year of publication
1999
Pages
107 - 110
Database
ISI
SICI code
Abstract
Objectives: to evaluate the safety, tolerability and efficacy of Efavirenz ((DMP 266) in 36 experienced asynptomatic or midly sintomatic HIV1 Infected patients (pts) who failed therapy with 2 NRTI and 1 PI. Methods: 36 experi enced pts were enrolled: the prior treatment was the association of: zidovu dine + lamivudine + nelfinavir or saquinavir (cohort I), and stavudine + la mivudine + ritonavir or indinavir (cohort 2). The treatment was switched to an association of stavudine + lamivudine and efavirenz (cohort 1); in the cohort 2 the therapy was changed in an association with zidovudine + lamivu dine and efavirenz. Results: after 24 weeks of treatment there was a signif icant increase of CD4 subset and a decrease of viral load. The treatment wa s well tolerated, 5.5% of pts had skin rash and transient dizziness (41%).