Switch therapy to nevirapine for protease inhibitor in HIV-1 positive patients with undetectable plasma viral load

Protease Inhibitors (PI) are frequently associated with side effects, poor adherence and long term toxcities. Therefore there is a need for long term. simple and well-tolerated regimen, wich will maintain virological suppress ion below the level of detection such as the nevirapine. So 15 patients wit h undetectable plasma viral load on PI therapy were switched to nevirapine regimen because there was intolerance to IF. One patient interrupted nevira pine for intolerance. Six patients had a viral load detectable after 3 mont hs post-switch, while 8 patients continued to maintain undetectable plasma viral load. Our study suggests that randomised studies comparing NNRTI swit ch versus maintenance of initial PI containing regimen are urgenttly requir ed to verify whether this type strategy is able.