One step preparation of 1,4-diketones from methyl ketones and alpha-bromomethyl ketones in the presence of ZnCl2 center dot t-BuOH center dot Et2NR as a condensation agent

1,4-Diketones have been prepared in one step From methyl ketones and alpha- bromomethyl ketones under the action of ZnCl2.t-BuOH.Et2NR as a condensatio n agent with moderate to high yields. The mechanistic pathway of the reacti on is proposed to go through aldol condensation of ketones followed by 1,3- dehydro-bromination of aldol products and cleavage of activated cyclopropyl intermediates.