Directed Evolution (DE)(1) is a proactive method to be used by a company en
gaged in the development of new products and processes. The method is for t
he preparation of a comprehensive set of scenarios that allows for the plan
ning and ongoing development of future generations of technological systems
. The objective of this paper is to present Directed Evolution as a method,
including its historical background, basic assumptions, procedure, and exa
mples of its application. (C) 2000 Elsevier Science Inc.