Synthesis and reactivity of imines derived from bisphosphonates and 3-phosphorylated 2-aza-1,3-dienes

The synthesis and some reactions of imines derived from aminoalkylbisphosph onates and 2-aza-1,3-butadienes is described. Bisphosphonylalkylimino compo unds are useful intermediates in the preparation of aminoalkylbisphosphonat e derivatives by reduction of the imino linkage with sodium triacetoxyboroh ydride as well as in the synthesis of 2-aza-1,3-butadienes by an olefinatio n reaction. The electrocyclization of phosphorylated 2-aza-1,3,5-trienes af forded substituted 2-phosphorylated pyridines. (C) 2000 Elsevier Science Lt d. All rights reserved.