Citation
Df. Taber et Q. Jiang, Preparation of ent-prostaglandin E-2, TETRAHEDRON, 56(33), 2000, pp. 5991-5994
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
56
Issue
33
Year of publication
2000
Pages
5991 - 5994
Database
ISI
SICI code
0040-4020(20000811)56:33<5991:POEE>2.0.ZU;2-W
Abstract
The enantiomeric prostaglandins, exemplified by ent-PGE(2), are apparently
produced in vivo by the nonenzymatic oxidation of arachidonic acid. To asse
ss the physiological activity of ent-PGE(2), it was necessary to prepare it
by total synthesis. The key transformation in this synthesis was the equil
ibration of the kinetically prepared ent-5-E-2t-isoprostane to ent-PGE(2).
(C) 2000 Elsevier Science Ltd. All rights reserved.