Efficient synthesis of purine analogues: an FeCl3-SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Authors
Dang, Q Brown, BS Erion, MD
Citation
Q. Dang et al., Efficient synthesis of purine analogues: an FeCl3-SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines, TETRAHEDR L, 41(34), 2000, pp. 6559-6562
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
34
Year of publication
2000
Pages
6559 - 6562
Database
ISI
SICI code
0040-4039(20000819)41:34<6559:ESOPAA>2.0.ZU;2-X
Abstract
6,8,9-Trisubstituted purine analogues were efficiently synthesized via cycl ization of 6-chloro-4,5-diaminopyrimidines and various aldehydes promoted b y FeCl3-SiO2. Fe(III) chloride on silica gel has a dual role of a dehydrati on agent and an oxidant, and was conveniently removed during work-up by fil tration. (C) 2000 Elsevier Science Ltd. All rights reserved.