Saxitoxin and neosaxitoxin as toxic principles of Alexandrium andersoni (Dinophyceae) from the Gulf of Naples, Italy

Authors
Ciminiello, P Fattorusso, E Forino, M Montresor, M
Citation
P. Ciminiello et al., Saxitoxin and neosaxitoxin as toxic principles of Alexandrium andersoni (Dinophyceae) from the Gulf of Naples, Italy, TOXICON, 38(12), 2000, pp. 1871-1877
Citations number
26
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICON
ISSN journal
00410101 → ACNP
Volume
38
Issue
12
Year of publication
2000
Pages
1871 - 1877
Database
ISI
SICI code
0041-0101(200012)38:12<1871:SANATP>2.0.ZU;2-W
Abstract
A clonal culture of Alexandrium andersoni, obtained from germination of a r esting cyst, collected From the Gulf of Naples, was found positive for PSP toxicity by mouse bioassay. The toxicity profile of this dinoflagellate con sists mainly of toxins belonging to the saxitoxin class, in particular of S axitoxin (STX) and Neosaxitoxin (NEO), as determined by a wide MS and H-1 N MR analysis. This represents the first report of the presence of A, anderso ni in the Mediterranean Sea, as well as of its toxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.