Little is known about the barriers which women living with HIV/AIDS encount
er that impede their adherence to antiretroviral medication regimens. Yet i
n order to design effective interventions to improve women's adherence, it
is first imperative to identify the factors that contribute to their non-ad
herence. The purpose of this study was to explore, from HIV-infected women
's own perspectives, the barriers they faced in adhering to combination ant
iretroviral therapies. Twenty HIV/-infected women were asked to keep a pers
onal journal for a period of one month. In the journals, women wrote about
what their lives were like while taking antiretroviral medications. Line-by
-line open coding was done to identify major ideas and themes within the jo
urnal entries. Results showed that women faced six main barriers to adheren
ce, those related to: (I) medication regimens, (2) side effects, (3) social
relationships, (4) medication beliefs, (5) daily schedules, and (6) body w
eight. The findings underscore the difficult nature: of the antiretroviral
regimens and illuminate the daily obstacles women face in adhering to thera
py. Interventions that target women's unique barriers are needed to improve
adherence to antiretroviral medication regimens.