Citation
Hp. Jankala et al., Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats, ALC ALCOHOL, 35(4), 2000, pp. 331-335
Citations number
22
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
07350414
→ ACNP
Volume
35
Issue
4
Year of publication
2000
Pages
331 - 335
Database
ISI
SICI code
0735-0414(200007/08)35:4<331:ROAITI>2.0.ZU;2-4
Abstract
We studied the effects of ethanol and acetaldehyde on myocardial gene expre
ssion of atrial natriuretic peptide (ANP) and growth of rats. Combined etha
nol and calcium carbimide treatment increased blood-acetaldehyde levels and
ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls
. The results suggest a role for acetaldehyde in the development of alcohol
ic heart dysfunction.