Association between heart rate-corrected QT interval and coronary risk factors in 2,894 healthy subjects (The DESIR study)

In the prospective Data from an Epidemiological Study on the Insulin Resist ance Syndrome, 2,894 healthy subjects aged 30 to 64 years had determination s of fasting glucose, insulin, serum lipid and fibrinogen concentrations, b lood pressures, body mass index, and waist-hip ratio, as well as tobacco an d alcohol consumptions and physical activity. A 12-lead electrocardiogram w ith automatic measurement of the QT interval was recorded and the formula u sed for heart rate correction was based on the best-fit regression between QT and heart rate. The QT duration was influenced by glucose homeostasis in both sexes, and increased in men with physical activity; there was a dose- effect relation for men who smoked.