Rl. Goldenberg et al., Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth, AM J OBST G, 183(2), 2000, pp. 469-475
OBJECTIVE: We sought to determine the range of fetal fibronectin Values in
the vagina from 8 to 22 weeks' gestation, the factors associated with both
low and high values, and whether high values are associated with gestationa
l age at birth.
STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a
prospective cohort study of 13,360 women being evaluated for participation
in the National Institute of Child Health and Human Development Maternal-Fe
tal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas
vaginalis. Fetal fibronectin values were correlated with gestational age at
screening, race, the presence of bacterial vaginosis and Trichomonas vagin
alis, and gestational age at delivery.
RESULTS: Vaginal fetal fibronectin values at each gestational age ranged fr
om unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL.
Fetal fibronectin values declined progressively with increasing gestational
age at sampling. Bacterial vaginosis and black race were associated with h
igher values, whereas nulliparity was associated with lower values. High va
lues after 13 weeks' gestation were associated with a 2- to 3-fold increase
d risk of subsequent spontaneous preterm birth overall and a 4-fold increas
ed risk of very early preterm birth.
CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks'
gestation are associated with a significantly increased risk of spontaneous
preterm birth.