Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth

Citation
Rl. Goldenberg et al., Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth, AM J OBST G, 183(2), 2000, pp. 469-475
Citations number
19
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
ISSN journal
00029378 → ACNP
Volume
183
Issue
2
Year of publication
2000
Pages
469 - 475
Database
ISI
SICI code
0002-9378(200008)183:2<469:VFFMF8>2.0.ZU;2-4
Abstract
OBJECTIVE: We sought to determine the range of fetal fibronectin Values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestationa l age at birth. STUDY DESIGN: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fe tal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vagin alis, and gestational age at delivery. RESULTS: Vaginal fetal fibronectin values at each gestational age ranged fr om unmeasurable to >1000 ng/mL, with median values always being <10 ng/mL. Fetal fibronectin values declined progressively with increasing gestational age at sampling. Bacterial vaginosis and black race were associated with h igher values, whereas nulliparity was associated with lower values. High va lues after 13 weeks' gestation were associated with a 2- to 3-fold increase d risk of subsequent spontaneous preterm birth overall and a 4-fold increas ed risk of very early preterm birth. CONCLUSION: Elevated vaginal fetal fibronectin levels from 13 to 22 weeks' gestation are associated with a significantly increased risk of spontaneous preterm birth.