Cardiotoxic transplacental effect of idarubicin administered during the second trimester of pregnancy

Authors
Achtari, C Hohlfeld, P
Citation
C. Achtari et P. Hohlfeld, Cardiotoxic transplacental effect of idarubicin administered during the second trimester of pregnancy, AM J OBST G, 183(2), 2000, pp. 511-512
Citations number
2
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
ISSN journal
00029378 → ACNP
Volume
183
Issue
2
Year of publication
2000
Pages
511 - 512
Database
ISI
SICI code
0002-9378(200008)183:2<511:CTEOIA>2.0.ZU;2-Q
Abstract
Polychemotherapy including idarubicin was administered during the second tr imester to treat acute lymphoblastic leukemia. The infant delivered at 28 w eeks' gestation had acute cardiac failure attributed to the cardiotoxic eff ect of idarubicin. Cardiotoxicity may be caused by idarubicin's biophysical properties that facilitate its transplacental passage. Idarubicin should b e used with extreme caution during pregnancy.