Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens

We report the use of polymerase chain reaction (PCR) techniques from a bron choalveolar lavage (BAL) specimen for the successful early diagnosis in a c ase of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypic al presentations of disseminated VZV frequently prolong the time required f or accurate diagnosis, resulting in increased morbidity, or mortality. Alth ough further investigation is necessary to determine the sensitivity and po sitive predictive value of this test, PCR analysis of bronchoscopic specime ns may expedite the diagnosis of disseminated VZV.