The promise of therapeutic drug monitoring in HIV infection

Antiretroviral drugs exhibit significant between-patient pharmacokinetic va riability. Over the past years, data have emerged demonstrating a link betw een antiretroviral drug concentrations and efficacy or side-effects. As a r esult, the issue of therapeutic drug monitoring for these compounds are ari sen; many published studies provided evidence that plasma concentrations co ntributes to therapeutic response. However, further information must be col lected to define more precisely the therapeutic concentrations and the indi cations of therapeutic drug-monitoring for each drug.