Guillain-Barre syndrome subsequent to Mycoplasma pneumoniae is uncommon and
difficult to confirm. We report one case, Clinical presentation and therap
y were unremarkable. The interest of antibiotics (preventive or curative) i
s unresolved. The pathophysiology remains hypothetical but Mycoplasma pneum
oniae and some surface gangliosides of peripheral nerves share homologous e
pitopes leading to the production of antibodies. Induced antibodies to gang
lioside may cross-react with neural tissues.