Sjogren's syndrome associated with multiple myeloma

Citation
E. Terpos et al., Sjogren's syndrome associated with multiple myeloma, ANN HEMATOL, 79(8), 2000, pp. 449-451
Citations number
21
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
ANNALS OF HEMATOLOGY
ISSN journal
09395555 → ACNP
Volume
79
Issue
8
Year of publication
2000
Pages
449 - 451
Database
ISI
SICI code
0939-5555(200008)79:8<449:SSAWMM>2.0.ZU;2-H
Abstract
Sjogren's syndrome (SS) is a chronic autoimmune disease of unknown etiology characterized by lymphocytic infiltration of the exocrine glands and a pol yclonal B-cell activation: it is demonstrated by the presence of multiple a utoantibodies against organ- and non-organ-specific autoantigens, SS is ass ociated with malignant lymphomas, Waldenstrom's macroglobulinemia and benig n monoclonal gammopathy, while its relationship with multiple myeloma is ex tremely rare. The association between multiple myeloma and rheumatoid arthr itis and other autoimmune diseases has been established, but it is not clea r why a B-cell proliferation like myeloma occurs more rarely than other B-c ell disorders in patients with SS, We describe a patient who presented with multiple myeloma and SS that might have existed for at least 2 years prior to the appearance of myeloma.