Alterations in coagulation after implantation of a pulsatile Novacor LVAD and the axial flow MicroMed DeBakey LVAD

Background. The MicroMed DeBakey left ventricular assist device (LVAD) is a chamber and valveless axial now blood pump. We investigated parameters of the coagulation system in patients after implantation of the axial now LVAD and patients following implantation of a pulsatile Novacor LVAD. Methods. Six consecutive patients of both groups were investigated over a p eriod of 6 weeks after implantation. beta-Thromboglobulin, platelet factor 4, factor XIIa, thrombin/antithrombin complexes, plasmin/alpha(2)-antiplasm in complexes, and D-Dimer levels were measured. Results. With the exception of the plasmin/alpha(2)-antiplasmin levels in t he Novacor group, all parameters were elevated in both groups. The levels o f beta-thromboglobulin, platelet factor 4, factor XIIa, and plasmin/alpha(2 )-antiplasmin were significantly increased in the axial now LVAD group. Conclusions. The axial flow LVAD strongly influences the systems of contact activation and fibrinolysis. The elevation of platelet proteins appears to follow platelet damage. Although no thromboembolic events were observed in both groups, elevation of thrombin/antithrombin complexes provides convinc ing evidence of an increased activation of the coagulation system and the c oncomitant risk for the development of thromboembolism. (C) 2000 by The Soc iety of Thoracic Surgeons.