TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy

Authors
Perilli, M Segatore, B De Massis, MR Riccio, ML Bianchi, C Zollo, A Rossolini, GM Amicosante, G
Citation
M. Perilli et al., TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy, ANTIM AG CH, 44(9), 2000, pp. 2537-2539
Citations number
21
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
9
Year of publication
2000
Pages
2537 - 2539
Database
ISI
SICI code
0066-4804(200009)44:9<2537:TANEBD>2.0.ZU;2-#
Abstract
new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mir abilis strain and in a Morganella morganii strain isolated in Italy in 1999 , Compared to TEM-1, TEM-72 contains the following amino acid substitutions : Q39K M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibit s an extended-spectrum activity, including activity against oxyimino-cephal osporins and aztreonam, Expression of bla(TEM-72) in Escherichia coli was c apable of decreasing the host susceptibility to the above drugs.