In vitro susceptibilities of 400 Spanish isolates of Neisseria gonorrhoeaeto gemifloxacin and 11 other antimicrobial agents

The in vitro activity of gemifloxacin versus those of 11 other antimicrobia l agents against 400 strains of Neisseria gonorrhoeae was determined by mic rodilution with supplemented GC agar. A total of 37.5% of the strains were B-lactamase positive. A total of 70 and 6.4% of the beta-lactamase-negative strains exhibited intermediate and high-level penicillin resistance, respe ctively, Ceftriaxone and gemifloxacin were the most active drugs (MICs at w hich 90% of isolates are inhibited, 0.01 versus 0.007 mu g/ml, respectively ), with 100% of strains inhibited by 0.12 mu g/ml.