In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs

Authors
Ruiz-Serrano, MJ Alcala, L Martinez, L Diaz, M Marin, M Gonzalez-Abad, MJ Bouza, E
Citation
Mj. Ruiz-serrano et al., In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs, ANTIM AG CH, 44(9), 2000, pp. 2567-2568
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
9
Year of publication
2000
Pages
2567 - 2568
Database
ISI
SICI code
0066-4804(200009)44:9<2567:IVAOSF>2.0.ZU;2-9
Abstract
Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, t rovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, an d grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC90] 1 mu g/ml), although ofloxacin also showed good activity, with an MIC90 of 2 mu g/ml, Trovafloxacin and gemifloxacin showed lower in vitro ac tivity, with MIC(90)s of 64 and 8 mu g/ml, respectively.