Efficacy of ampicillin plus arbekacin in experimental rabbit endocarditis caused by an Enterococcus faecalis strain with high-level gentamicin resistance

Authors
Kak, V Donabedian, SM Zervos, MJ Kariyama, R Kumon, H Chow, JW
Citation
V. Kak et al., Efficacy of ampicillin plus arbekacin in experimental rabbit endocarditis caused by an Enterococcus faecalis strain with high-level gentamicin resistance, ANTIM AG CH, 44(9), 2000, pp. 2545-2546
Citations number
19
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
9
Year of publication
2000
Pages
2545 - 2546
Database
ISI
SICI code
0066-4804(200009)44:9<2545:EOAPAI>2.0.ZU;2-B
Abstract
Enterococcus faecalis LC40 is an ampicillin-susceptible clinical isolate wi th high-level gentamicin resistance due to the aac(6')-Ie-aph(2 ")-Ia amino glycoside resistance gene. The combination of ampicillin plus arbekacin red uced mean bacterial vegetation counts significantly more than ampicillin al one or ampicillin pins gentamicin in a rabbit model of aortic-valve endocar ditis caused by E. faecalis LC40.