Fluconazole penetration into the pancreas

Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequen cy of fungal superinfection in patients with pancreatic necrosis Is increas ing. In this study we analyzed the penetration of fluconazole into the huma n pancreas and in experimental acute pancreatitis. In human pancreatic tiss ues, the mean fluconazole concentration was 8.19 +/- 3.38 mu g/g (96% of th e corresponding concentration in serum). In experimental edematous and necr otizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into t he pancreas is sufficient to prevent and/or treat fungal contamination in p atients with pancreatic necrosis.