Recent studies of nearby spiral galaxies suggest that photodissociation reg
ions (PDRs) are capable of producing much of the observed H I in galaxy dis
ks. In that case, measurements of the observed H I column density and the f
ar-ultraviolet (FUV) photon flux responsible for the photodissociation proc
ess provide a new probe of the volume density of the local underlying molec
ular hydrogen. We develop the method and apply it to the giant Scd spiral g
alaxy M101 (NGC 5457). The H I column density and amount of FUV emission ha
ve been measured for a sample of 35 candidate PDRs located throughout the d
isk of M101 using the Very Large Array and the Ultraviolet Imaging Telescop
e. We find that, after correction for the best-estimate gradient of metalli
city in the interstellar medium (ISM) of M101 and for the extinction of the
ultraviolet emission, molecular gas with a narrow range of density from 30
-1000 cm(-3) is found near star-forming regions at all radii in the disk of
M101 out to a distance of 12' approximate to 26 cm kpc, close to the photo
metric limit of R-25 approximate to 13.'5.
In this picture, the ISM is virtually all molecular in the inner parts of M
101. The strong decrease of the H I column density in the inner disk of the
galaxy at R-G < 10 kpc is a consequence of a strong increase in the dust-t
o-gas ratio there, resulting in an increase of the H-2 formation rate on gr
ains and a corresponding disappearance of hydrogen in its atomic form.