Synthesis and antimicrobial activity of squalamine analogue

Authors
Kim, HS Choi, BS Kwon, KC Lee, SO Kwak, HJ Lee, CH
Citation
Hs. Kim et al., Synthesis and antimicrobial activity of squalamine analogue, BIO MED CH, 8(8), 2000, pp. 2059-2065
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
8
Year of publication
2000
Pages
2059 - 2065
Database
ISI
SICI code
0968-0896(200008)8:8<2059:SAAAOS>2.0.ZU;2-N
Abstract
Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine m oiety was introduced via reductive amination of an appropriately functional ized 3 beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triac etoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobi al activity than squalamine. (C) 2000 Elsevier Science Ltd. All rights rese rved.