Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

Authors
Chan, WN Hadley, MS Darling, JD Herdon, HJ Orlek, BS Riley, GJ Stead, REA Stean, TO Thompson, M Upton, N Ward, RW
Citation
Wn. Chan et al., Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides, BIO MED CH, 8(8), 2000, pp. 2085-2094
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
8
Year of publication
2000
Pages
2085 - 2094
Database
ISI
SICI code
0968-0896(200008)8:8<2085:EOASOA>2.0.ZU;2-R
Abstract
SAR studies around a series of N-(tetrahydroisoquinolinyl)-2-methoxybenzami des identified by high-throughput screening at the novel SB-204269 binding site, have provided compounds such as 13, 29-33 with high affinity and exce llent anticonvulsant activity in animal models. (C) 2000 Elsevier Science L td. All rights reserved.