CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound

Authors
Forbes, IT Cooper, DG Dodds, EK Hickey, DMB Ife, RJ Meeson, M Stockley, M Berkhout, TA Gohil, J Groot, PHE Moores, K
Citation
It. Forbes et al., CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound, BIOORG MED, 10(16), 2000, pp. 1803-1806
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
16
Year of publication
2000
Pages
1803 - 1806
Database
ISI
SICI code
0960-894X(20000821)10:16<1803:CRACOA>2.0.ZU;2-P
Abstract
A weak HTS hit at the CCR2B receptor has been converted into a potent antag onist by array SAR studies. Selectivity over the closely related CCR5 recep tor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.