Sj. Gregson et al., Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines, BIOORG MED, 10(16), 2000, pp. 1845-1847
A series of novel C2-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PB
Ds) has been synthesised via a versatile pro-C2 ketone precursor. C2-exo-un
saturation enhances both DNA-binding reactivity and in vitro cytotoxic pote
ncy. (C) 2000 Elsevier Science Ltd. All rights reserved.