Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases

Authors
Forrest, AK Jarvest, RL Mensah, LM O'Hanlon, PJ Pope, AJ Sheppard, RJ
Citation
Ak. Forrest et al., Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases, BIOORG MED, 10(16), 2000, pp. 1871-1874
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
16
Year of publication
2000
Pages
1871 - 1874
Database
ISI
SICI code
0960-894X(20000821)10:16<1871:AAAASI>2.0.ZU;2-0
Abstract
Aminoalkyl adenylates and aminoacyl sulfamates derived from arginine, histi dine and threonine, have been prepared and tested as inhibitors of their co gnate Staphylococcus aureus aminoacyl tRNA synthetases. The arginyl derivat ives were both potent nanomolar inhibitors of the Class I arginyl tRNA synt hetase whereas for the Class II histidyl and threonyl tRNA synthetases, the acyl sulfamates were potent inhibitors but the adenylates had very little affinity. (C) 2000 Elsevier Science Ltd. All rights reserved.