Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers

Authors
Manna, F Chimenti, F Bolasco, A Bizzarri, B Botta, M Tafi, A Filippelli, A Rossi, S
Citation
F. Manna et al., Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers, BIOORG MED, 10(16), 2000, pp. 1883-1885
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
16
Year of publication
2000
Pages
1883 - 1885
Database
ISI
SICI code
0960-894X(20000821)10:16<1883:SAPBEO>2.0.ZU;2-T
Abstract
The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a . h, calcium en try blockers related to diltiazem, is described starting from 1,3-diaryl-2- propen-1-ones 5. On preliminary pharmacological tests all compounds are act ive and some of them show calcium antagonistic activity superior or compara ble to diltiazem. (C) 2000 Elsevier Science Ltd. All rights reserved.