C. Mitchell et al., The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study, BR J CANC, 83(5), 2000, pp. 602-608
The aims of the UKW2 study were: (1) to further refine treatment for stage
I and II favourable histology (FH) patients; (2) to consolidate the UKW1 re
sults for stage III FH patients; (3) to improve the outlook for patients wi
th inoperable primary tumours and those patients with stage IV and unfavour
able histology disease. Treatment consisted of primary nephrectomy, whereve
r possible, followed by chemotherapy and radiotherapy, as dictated by stage
and histology. Treatment was refined successfully for stage I and II FH pa
tients. The 4-year event-free survival for these two groups was 94% and 91%
, respectively. Stage III FH patients had a 4-year event free survival of 8
4%, The outlook for patients with clear cell sarcoma of the kidney is as go
od as for patients with favourable histology, whilst that for patients with
anaplastic or rhabdoid variants remains poor. The outlook for the majority
of children with Wilms' tumour is now excellent. (C) 2000 Cancer Research
Campaign.