The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study

Citation
C. Mitchell et al., The treatment of Wilms' tumour: results of the United Kingdom Children's Cancer Study Group (UKCCSG) second Wilms' tumour study, BR J CANC, 83(5), 2000, pp. 602-608
Citations number
24
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
83
Issue
5
Year of publication
2000
Pages
602 - 608
Database
ISI
SICI code
0007-0920(200009)83:5<602:TTOWTR>2.0.ZU;2-L
Abstract
The aims of the UKW2 study were: (1) to further refine treatment for stage I and II favourable histology (FH) patients; (2) to consolidate the UKW1 re sults for stage III FH patients; (3) to improve the outlook for patients wi th inoperable primary tumours and those patients with stage IV and unfavour able histology disease. Treatment consisted of primary nephrectomy, whereve r possible, followed by chemotherapy and radiotherapy, as dictated by stage and histology. Treatment was refined successfully for stage I and II FH pa tients. The 4-year event-free survival for these two groups was 94% and 91% , respectively. Stage III FH patients had a 4-year event free survival of 8 4%, The outlook for patients with clear cell sarcoma of the kidney is as go od as for patients with favourable histology, whilst that for patients with anaplastic or rhabdoid variants remains poor. The outlook for the majority of children with Wilms' tumour is now excellent. (C) 2000 Cancer Research Campaign.