Simultaneous presence of t(2;8)(p12;q24) and t(14;18) (q32;q21) in a B-cell lymphoproliferative disorder with features suggestive of an aggressive variant of splenic marginal-zone lymphoma

Authors
Batanian, JR Dunphy, CH Richart, JM Petruska, PJ Perkins, SL
Citation
Jr. Batanian et al., Simultaneous presence of t(2;8)(p12;q24) and t(14;18) (q32;q21) in a B-cell lymphoproliferative disorder with features suggestive of an aggressive variant of splenic marginal-zone lymphoma, CANC GENET, 120(2), 2000, pp. 136-140
Citations number
18
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
120
Issue
2
Year of publication
2000
Pages
136 - 140
Database
ISI
SICI code
0165-4608(20000715)120:2<136:SPOTAT>2.0.ZU;2-A
Abstract
We report a case of an aggressive variant of splenic marginal-zone lymphona (SMZL) with circulating villous lymphocytes. The karyotype of all examined cells bad multiple structural and numerical abnormalities, including two l ymphoma characteristic translocations, t(2;8)(p12;q24) and t(14;18)(q32;q21 ). Based on a literature review of cytogenetic aberrations of splenic lymph oma with villous lymphocytes (SLVL) and SMZL, this is apparently the first documentation of these two translocations in a case of SMZL, and could refl ect the heterogeneity of the disorder. (C) 2000 Elsevier Science Inc. All r ights reserved.