Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia

Authors
Anguita, E Barrio, CG Gonzalez, FA Ferro, MT del Potro, E Ropero, P Villegas, A
Citation
E. Anguita et al., Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia, CANC GENET, 120(2), 2000, pp. 144-147
Citations number
15
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
120
Issue
2
Year of publication
2000
Pages
144 - 147
Database
ISI
SICI code
0165-4608(20000715)120:2<144:AOTAAT>2.0.ZU;2-8
Abstract
The implication of MLL gene rearrangements in the prognosis of acute myelob lastic leukemia is an issue of considerable current interest. We report a c ase of a young man who initially presented with a pancytopenia and went on 50 develop a highly-aggressive acute myeloblastic leukemia. At this time, t he karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluor escence in situ hybridization (FISH) and the MLL/AF4 rearrangement by rever se transcriptase-polymerase chain reaction (RT-PCR). (C) 2000 Elsevier Scie nce Inc. All rights reserved.