Trisomy/tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia

Authors
Ferro, MT Vazquez-Mazariego, Y Ramiro, S Santiago, MF Garcia-Sagredo, JM Nunez, R Hernandez, JM San Roman, C
Citation
Mt. Ferro et al., Trisomy/tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia, CANC GENET, 120(2), 2000, pp. 163-165
Citations number
9
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
120
Issue
2
Year of publication
2000
Pages
163 - 165
Database
ISI
SICI code
0165-4608(20000715)120:2<163:TOC8A+>2.0.ZU;2-K
Abstract
We report three cases of tetrasomy 8 associated with myeloid disease. Two p atients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromo some 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long ar m chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic fin ding suggests the importance of the genes located in the long arms of chrom osome 8. (C) 2000 Elsevier Science Inc. All rights reserved.